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Simulations DDDPlus 5.0

Simulations Plus DDDPlus (Dose Disintegration and Dissolution Plus)是一款先进的制剂体外崩解与溶出模拟软件,用于模拟API及其制剂(粉末、速释片剂、速释胶囊、迟释制剂、缓释制剂等)在体外不同溶出条件下的溶出或释放行为,以评估不同处方、溶出条件等对体外溶出曲线的影响,帮助筛选制剂处方、制定体外溶出条件,减少体外溶出试验的数量,提高药品研发效率。
Simulations DDDPlus将溶出过程中涉及到的一系列因素整合到各个方程式,以模拟API及制剂的溶出曲线,整个模型考虑了原辅料间的相互作用、粒度分布、溶出介质表层及内部的pH、机器的转速等多种条件对溶出的影响。


Simulations DDDPlus 5.0 (制剂体外崩解与溶出模拟) | 160 mb

DDDPlus Version 5.0 extends our lead in this area by adding valuable new functionalities that will enable formulation scientists in both innovator and generic companies, as well as regulatory agencies, to gain insight into the behaviors of various formulations for pharmaceutical dosage forms. Several of the significant enhancements include:
–integration of the optional add-on ADMET Predictor Module
–simulation of in vitro dissolution of coated bead, coated tablet, and bilayer tablet dosage forms
–addition of tablet disintegration and porosity models
–expanded library of dissolution apparatus to include the Pion μDISS Profiler™ experiment
–improved 3D Parameter Sensitivity Analysis mode.

Language: English
Operating Systems: Windows 7/8.x

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